N-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR SALTS, METHOD OF PREPARATION THEREOF, INTERMEDIATE COMPOUNDS AND PHARMACEUTICAL COMPOSITION WITH ANGIOTENSINE II ANTAGONIST ACTIVITY Russian patent published in 1998 - IPC

FIELD: preparation of biologically active substances. SUBSTANCE: compounds of invention have general formula where R₁ and R₂, the same or different, are hydrogen, C₁-C₆-alkyl, (C₁-C₄)-alkoxyl, amino, aminomethyl, carboxyl, C₁-C₄-alkoxycarbonyl, cyano, tetrazolyl, methyltetrazolyl, methylsulfonylamino, trifluoromethylsulfonylamino, trifluoromethylsulfonylaminomethyl, N-cyanoacetamido, N- hydroxyacetamido, N-(4-carboxy-1,3-thizol-2-yl)acetamido, ureido, 2- cyanoguanidinocarbonyl, or 2-cyanoguanidinomethyl, provided that at least one R₁ or R₂ is not hydrogen; R₃ is hydrogen, C₁-C₆-alkyl that may be substituted by one or more halogen atoms, C₂-C₆-alkenyl, C₃-C₇- cycloalkyl, phenyl, phenyl-C₁-C₃-alkyl, phenyl-C₂-C₃-alkenyl (indicated phenyl groups being optionally substituted by one ore more halogen atoms), C₁-C₄-alkyl, halo-C₁-C₄-alkyl, polyhalo-C₁-C₄-alkyl, hydroxyl, or C₁-C₄-alkoxyl; R₄ is C₁-C₄-alkyl optionally substituted by one or more halogen atoms; R₅-cycloalkyl or C₃-C₇-cycloalkylmethyl optionally substituted by one or more halogen atoms; each of R₄ and R₅ groups may also be cyclopropyl; X is oxygen or sulfur; z= t=0 or one of them is 0 and other 1. EFFECT: provided new useful biologically active substances. 10 cl, 1 tbl