METHOD OF SYNTHESIS OF 9-(2-HYDROXY)-ETHOXYMETHYLGUANINE Russian patent published in 1999 - IPC

FIELD: organic chemistry and technology, biochemistry. SUBSTANCE: invention relates to the improved method of synthesis of aciclovir. Method involves an alkylation of N-formylguanine with 2-oxa-1,4-diacylhydroxybutane and hydrolysis of an intermediate compound in the presence of acid catalyst. Aciclovir - 9-(2-hydroxy)-ethoxymethylguanine is the known antiviral agent. Method provides synthesis of aciclovir without its nonfavorable by-side 7-isomer of the end product practically. EFFECT: improved method of synthesis. 7 cl, 2 dwg, 4 ex