NEW DERIVATIVES OF HYDROXAMIC ACID USEFUL FOR TREATMENT OF PATIENTS WITH DISEASES ASSOCIATED WITH DEGENERATION OF CONNECTIVE TISSUE Russian patent published in 2001 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of hydroxamic acid of the formula (I) where X means -CH₂-, -NR₅-, -C(O); Y means -CH₂-, -NR₅- under condition that if X means -NR₅- then Y means -CH₂-; R₁ means H, C₁-C₂₀-alkyl, -(CH₂)_j-aryl, -(CH₂)_j-cycloalkyl and others; R₂ means H, C₁-C₂₀-alkyl, -(CH₂)_j -R₈, -(CH₂)_j-NR₆R₇, -(CH₂)_j-NR₅-;-C(O)R₅ and others; R₃ means H, C₁-C₆-alkyl, -(CH₂)_j-aryl, -(CH₂)_j-C_3-6-cycloalkyl and others; R₅ means H, C₁-C₆-alkyl possibly substituted with 1-3 halogen atoms and others; R₆ and R₇ are similar or distinct and mean H, C₁-C₆-alkyl and others; R₈ means -S-R₈ and others; R₉ is halogen atom, C₁-C₆-alkyl and others; R₁₀ is H, aryl-phenyl possibly substituted one; Het is pyridinyl, thienyl and others; i = 1-6; j = 0-4. Compounds of the formula (I) inhibit metalloproteinase matrix excess that ensures to use their in pharmaceutical composition. EFFECT: new compounds indicated above, valuable medicinal properties. 14 cl, 1 tbl, 9 dwg, 209 ex