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2 125 571

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(51)

IPC

(21) (22)

Application

96111026/04, 1996-06-05

(22)

Actual filing date

1996-06-05

(45)

Published

1999-01-27

(72)

Inventor

Linne A.Khandan'JanRobert L.KhendriksonFillip Dzh.DzhonsonTomas A.MorrisTimoti Norris

(73)

Holder

Pfajzer Ink.

7-([-([1α,5α,6α]]-6-AMINO-3-AZABICYCLO-[3,1,0]-HEX-3-YL)-6-FLUORO-1- -(2,4-DIFLUOROPHENYL)-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYRIDINE-3- -CARBOXYLIC AND METHANESULFONIC ACIDS SALT AND A METHOD OF ITS SYNTHESIS Russian patent published in 1999 - IPC

Abstract RU 2125571 C1

FIELD: organic chemistry. SUBSTANCE: invention relates to synthesis of 7-([-([1α,5α,6α]] -6-amino-3-azabicyclo-[3,1,0] - -hex-3-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo- -1,8-naphthyridine-3-carboxylic and methanesulfonic acids salt. Salt or monohydrate of the above indicated compound exhibiting properties that are distinct from that of the end product (by data based on roentgenogram pattern of powder fraction) is boiled or heated to 80-85 C in the presence of alcohol or its mixture with aprotonic cosolvent. Synthesized compound shows favorable stability and can be used as an antibacterial agent. EFFECT: improved method of synthesis. 2 cl, 6 ex

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RU 2 125 571 C1

Authors

Linne A.Khandan'Jan

Robert L.Khendrikson

Fillip Dzh.Dzhonson

Tomas A.Morris

Timoti Norris

Dates

1999-01-27—Published

1996-06-05—Filed