FIELD: chemical industry. SUBSTANCE: described is method of preparing trovafloxacin by reacting 7-chloro- 1-(2,4-difluoropheny-6-fluoro-1,4- dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid with azobicyclo [3.1.0] hexyl derivative. Trovafloxacin is prepared without use and subsequent removal of protective groups on external aminogroup, thus making it possible to save time and cut down cost of synthesis. EFFECT: more efficient preparation method. 6 cl, 8 ex
Title |
Year |
Author |
Number |
AZABICYCLO-QUINOLONE CAROBOXYLIC ACIDS OR THEIR PHARMACEUTICALLY ACCEPTABLE ACID-ADDITIVE SALTS AND INTERMEDIATE PRODUCTS FOR THEIR SYNTHESIS |
1989 |
- Kehtrin Ehlizabet Brajti[Us]
|
RU2049777C1 |
7-([-([1α,5α,6α]]-6-AMINO-3-AZABICYCLO-[3,1,0]-HEX-3-YL)-6-FLUORO-1- -(2,4-DIFLUOROPHENYL)-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYRIDINE-3- -CARBOXYLIC AND METHANESULFONIC ACIDS SALT AND A METHOD OF ITS SYNTHESIS |
1996 |
- Linne A.Khandan'Jan
- Robert L.Khendrikson
- Fillip Dzh.Dzhonson
- Tomas A.Morris
- Timoti Norris
|
RU2125571C1 |
NEW DERIVATIVES OF PYRIDONE CARBOXYLIC ACIDS, METHOD AND INTERMEDIATE COMPOUNDS FOR THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATING PATIENTS WITH INFECTIOUS DISEASES |
1993 |
- Kim Chung Sup
- Kim Chin Vung
- Li Che Mok
- Cho Il Khvan
- Jun Eng Sik
- Shin Jung Chun
- Li Ki Khi
- Kim Che Khak
- Jung Eng Khvan
- Anseung Kho
|
RU2161154C2 |
METHOD OF TREATMENT OF INFECTIOUS DISEASES CAUSED BY HELICOBACTER PYLORI |
1995 |
- Artur E.Dzhirard
- Tomas D.Gutz
|
RU2114615C1 |
POLYMORPHES 6-N-(L-ALA-L-ALA) OF TROVAFLOXACINE |
1996 |
- Timoti Norris
- Dzhejms Dzh. Makgarri
- Duglas Dzh. M. Allen
|
RU2151152C1 |
INTERMEDIATES AND METHOD OF PREPARING NAPHTHIRIDONE CARBOXYLIC ACID SALTS |
1994 |
- Tamim F.Brejsh
- Darrell E.Foks
- Timoti Norris
- Piter R.Rouz
|
RU2147303C1 |
OXAZOLIDINONE DERIVATIVES |
2001 |
- Mekhta Anita
- Arora Sudershan K.
- Das Bisvadzhit
- Rehj Abkhidzhit
- Rudra Sonali
- Rattan Ashok
|
RU2292345C9 |
PYRAZOLO[1,5-A]PYRIMIDINE COMPOUND |
2017 |
- Clark Richard
- Kawahara, Tetsuya
- Iida, Daisuke
- Hirota, Shinsuke
- Kamada, Yasuaki
- Ohfusa Toshiyuki
- Yoneda, Naoki
- Matsuura, Fumiyoshi
- Yasui, So
|
RU2739983C2 |
METHOD OF SYNTHESIS OF DIOXOAZABICYCLOHEXANES |
1996 |
- Stiven Dzhejms Rehj
- Dzhon Artur Rampas
|
RU2156238C2 |
OXAZOLIDINONE ANTIBIOTICS SUBSTITUTED BY CYCLOPROPYL GROUP, AND THEIR DERIVATIVES |
2004 |
|
RU2348628C2 |