NEW DERIVATIVES OF PYRIDONE CARBOXYLIC ACIDS, METHOD AND INTERMEDIATE COMPOUNDS FOR THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATING PATIENTS WITH INFECTIOUS DISEASES Russian patent published in 2000 - IPC

FIELD: organic chemistry, pharmacy, medicine. SUBSTANCE: invention describes novel derivatives of pyridone carboxylic acid and their pharmaceutically acceptable salts and physiologically hydrolisable esters of the formula (I) where R₁ means lower alkyl, C₃-C₆-cycloalkyl or substituted or unsubstituted phenyl group; R₂ means hydrogen atom or lower alkyl or amino-group; A means nitrogen atom or the group C-X where X means hydrogen or halogen atom or alkoxy-group and Z means the group of the formula (II) where n = 1 or 2; R₃ and R₄ each means hydrogen atom or the group of lower alkyl under condition that if n = 2 then one of R₃ and R₄ means hydrogen atom; R₅ and R₆ each means hydrogen atom or hydroxy-group of lower alkyl or amino-group that is unsubstituted or unsubstituted with the group of lower alkyl under condition that one of R₅ and R₆ is hydrogen atom and if n = 1 and one of R₅ and R₆ means amino-group then one of R₃ and R₄ is not hydrogen atom; R₇ means hydrogen atom. Compounds of the formula (I) show strong effects and broad spectrum of antibacterial activity. Invention describes also method and intermediate compounds for synthesis of proposed substances, pharmaceutical composition and method of treatment of patients with infectious diseases. EFFECT: new compounds indicated above, improved method of synthesis. 7 cl, 3 tbl