BENZIMIDAZOLE DERIVATIVES, TAUTOMERS OR SALTS THEREOF AND DRUG HAVING ANTAGONISTIC ANGIOTENSINE II EFFECT Russian patent published in 1999 - IPC

FIELD: medicine. SUBSTANCE: present invention describes benzimidazole derivatives of formula I: wherein R₁- is C_1-3 alkyl; R₂ is 5-6 or 7-membered alkyleneimino group in which one methylene group is leneimino group in which one methylene group is substituted by sulfonyl group substituted in position I by alkyl benzimidazole-2- -yl or 4,5,6,7-tetrahydrobenzimidazol-2-yl, imidazo (1,2- a)pyridin-2-yl, 3-chloro-5,6,7,8-tetrahydroimidazo (1,2- a) pyrazin-2-yl; R₃ is alkyl, C_3-5 cycloalkyl or alkoxy; R₄ is tatrazolyl substituted in position 1 or 2 by R_a-CO-O-CH₂; R_b-CO-O-(R_cCH)-OCO-R₂O-CO- and R_bO-CO-O(R_cCH)-O-CO,; R_a R_b are C_1-6-alkyl, C_5-7-cycloalkyl; R_c is hydrogen or methyl, tautomers or salts thereof. Compounds I widen range of benzimidazole derivatives having antagonistic angiotensine II effect. EFFECT: improved properties of the drug. 3 cl, 26 ex