FIELD: organic chemistry of heterocyclic compounds, biochemistry. SUBSTANCE: invention relates to novel pyrimido[5,4-d]-pyrimidines of the general formula (I) 
and medicinal agents exhibiting properties of tyrosine kinase inhibitor of the growth epidermal factor receptors family based on thereof. In compounds of the general formula (I) Ra means hydrogen atom; Rb means 3-chlorophenyl, 3-chloro-4-fluorophenyl, 3-(1,1,2,2-tetrafluoroethoxy)phenyl, 4-amino-3,5-dichlorophenyl, 4-(benzyl)phenyl, 3-(benzyloxy)phenyl, 4-(benzyloxy)phenyl, 3-hydroxymethylphenyl, biphenyl-4-yl, 3-phenoxyphenyl, 4-phenoxyphenyl, 3-trifluoromethoxyphenyl, 4-(benzyloxy)-3-chlorophenyl, 3-chloro-4-phenoxyphenyl, 3-chloro-4-cyanophenyl or 4-chloro-3-cyanophenyl group; or Ra and Rb in common with nitrogen atom locating between them mean indoline-1-yl or 1,2,3,4-tetraquinoline-1-yl group and so on. Invention relates also to a medicinal agent containing compound or physiologically acceptable salt of compounds of the formula (I) and if necessary one or some inert carriers and/or vehicles. EFFECT: valuable medicinal properties of compounds. 5 cl
| Title | Year | Author | Number |
|---|---|---|---|
| CYCLIC NITROGEN-CONTAINING DERIVATIVES, MIXTURE OF THEIR ISOMERS, INDIVIDUAL ISOMERS OR THEIR SALTS | 1994 |
|
RU2126002C1 |
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|
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| CYCLIC IMINO-DERIVATIVES, THEIR ISOMER MIXTURES, ENANTIOMERS, DIASTEREOMERS OR PHYSIOLOGICALLY TOLERATED SALTS SHOWING ANTITHROMBOTIC ACTION | 1991 |
|
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| DERIVATIVES OF DIAZEPINONE, MIXTURES OF THEIR ISOMERS AND THEIR SALTS | 1992 |
|
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| BENZIMIDAZOLE DERIVATIVES, TAUTOMERS OR SALTS THEREOF AND DRUG HAVING ANTAGONISTIC ANGIOTENSINE II EFFECT | 1993 |
|
RU2126401C1 |
| ARYLIDENE-OR ARYLALKYL-1-AZACYCLOALKANE DERIVATIVES, MIXTURES OF ISOMERS THEREOF OF ISOMERS THEREOF OF INDIVIDUAL ISOMERS OR SALTS | 1993 |
|
RU2126400C1 |
| DERIVATIVES OF PYRIDINE, THEIR ENANTIOMERS, CIS- OR TRANS-ISOMERS AND THEIR SALTS AND PHARMACEUTICAL COMPOSITION | 1992 |
|
RU2119915C1 |
| BENZIMIDAZOLE DERIVATIVES, MIXTURE OF THEIR ISOMERS, INDIVIDUAL ISOMERS, OR THEIR ACID-ADDITIVE SALTS SHOWING PHARMACOLOGICAL ACTIVITY | 1992 |
|
RU2026861C1 |
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|
SU1731061A3 |
