FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of benzimidazole of the general formula (I) 
where R1 - methyl; R2 is benzimidazole-2-yl possibly substituted with methyl at position 1, imidazole-4-yl substituted with C1-3-alkyl at position 1 and substituted with morpholino-group, 5,6,7,8-tetra- -hydroimidazo[1,2-a] pyridine-2-yl or propanesultm-1-yl at position 2; R3 is C2-4-alkyl; R4 is amino-, sulfonyl-group, substituted dimethylaminocarbonylamino-, cycloalkylaminocarbonyl- -amino- and benzylaminocarbonylamino-group or their salts. Compounds show an antagonistic activity with respect to angiotensin. EFFECT: valuable pharmacological activity of compounds. 5 cl, 1 tbl, 20 ex
| Title |
Year |
Author |
Number |
| BENZIMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITION SHOWING ANTAGONISTIC ACTIVITY WITH RELATION TO ANGIOTENSIN BASED ON THEREOF |
1992 |
- Norbert Khauel'[De]
- Bertkhol'D Narr[De]
- Uve Ris[De]
- Zhak Fan Meel'[De]
- Vol'Fgang Vinen[De]
- Mikhael' Ehnttserot[De]
|
RU2053229C1 |
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1993 |
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- Uve Ris
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- Mikhael' Ehnttserot
|
RU2126401C1 |
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0 |
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|
SU1836357A3 |
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- Iokhannes Vajzenberger[De]
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1992 |
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1991 |
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|
RU2081870C1 |
