PHOSPHOLIPID DERIVATIVES, A METHOD OF THEIR SYNTHESIS, A PHARMACEUTICAL COMPOSITION BASED ON SAID, METHODS OF A PHARMACEUTICAL COMPOSITION PREPARING Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes compounds of the formula (I) where R⁵ is a linear or branched C₁₀-C₂₄-alkyl residue that can has also 1-3 double and/or triple bonds; A means a simple bond or one of groups of the formulas (II) -CH₂-CH₂-CH₂-O- (II), (III) -CH₂-CH₂-O- (III), (IV) , (V) , (VI) being R⁷ means linear C₁-C₄--alkyl group and groups (II)-(VI) are oriented so that oxygen atom is bound with phosphorus atom of compound (I); X means oxygen or sulfur atom; A′- means linear or branched C₂-C₁₀--alkyl residue; R⁶ is Y-(R⁸R⁹R¹⁰) where R⁸,R⁹,R¹⁰ are similar or distinct and they mean independently each of other hydrogen, linear, branched or cyclic C₁-C₆-alkyl residue, or two residues can form a ring; Y means P, As, Sb or B. Method of synthesis involves interaction of compound of the formula (VII) R⁵-X-A-H (VII) where values for R⁵, X and A are indicated above with phosphorus oxychloride in solvent medium or without its. The synthesized substance is subjected for interaction with a compound of the formula (VIII): HO-A′-R⁶ where values A′ and R⁶ are indicated above followed by hydrolysis. Invention proposes also a pharmaceutical composition showing antitumor and/or antileishmaniosis effect that contains at least a single compound of the formula (I) as an active component and taken at effective amount, and also to a method of preparing a pharmaceutical composition showing antitumor and/or antileishmaniosis effect that involves mixing one or more compounds of the formula (I) with addition of one or more a pharmaceutically acceptable special additions followed by processing the obtained mixture to the usual medicinal forms. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 6 cl, 29 ex