PHOSPHOLIPID DERIVATIVES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND A METHOD OF ITS PREPARING Russian patent published in 1998 - IPC

FIELD: organic chemistry, lipids. SUBSTANCE: invention describes new compounds of the general formula (I) where R means alkyl radical with unbranched or branched chain with 10-24 carbon atoms that can contain double or triple bonds; R¹ and R² mean independently hydrogen or each unbranched, branched cyclic saturated or nonsaturated alkyl residue with 1-6 carbon atoms that can contain also Cl-, OH- or NH₂-group being two these radicals can be fused to the ring; A means simple bond or one of groups of formulas: -CH₂-CH₂-CH₂-O--O- (II), -CH₂-CH₂-O- (III), -CH₂-CH(CH₃)-O--O- (IV), -S-(CH₂)₈-O- (V) and group of the formula (VI) being groups (II) a (VI) are oriented so that oxygen atom is bound with phosphorus atom. In compound (I) X means oxygen or sulfur atom, or NH if A - simple bond, or means oxygen or sulfur atom if A - one of groups -CH₂-CH₂-CH₂-O- and -CH₂-CH(CH₃)-O- ; "Y" = 0 or natural number from 1 to 3; m and n = 0 or natural numbers independently at condition that m + n = 2-8. Invention describes also method of synthesis of phospholipid derivatives of the general formula (I) , pharmaceutical composition and a method of its preparing. EFFECT: improved method of synthesis. 9 cl, 1 tbl