DERIVATIVES OF N-PHENYL-2-PYRIMIDINEAMINE OR THEIR SALTS AND PHARMACEUTICAL COMPOSITION BASED ON SAID SHOWING ANTITUMOR ACTIVITY Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of N-phenyl-2-pyrimidineamine of the formula (I) where R means pyridyl bound with carbon atom or N-oxidopyridyl; R₂,R₃,R₆,R₈,R₉ - hydrogen; R₄ - hydrogen or lower alkyl; R₅ - H, lower alkyl or trifluoromethyl; R₇ - nitro- -group, fluoro-substituted lower alkoxyl or a residue of the formula (II): -N(R₉)-C(O)-R₁₀ where R₁₀ - pyridyl bound by carbon atom, C_5-7-alkyl, thienyl, 2-naphthyl, cyclohexyl or phenyl optionally substituted with halide, cyano-group, lower alkoxyl, carboxyl, lower alkyl or 4-methylpiperazinoylmethyl, or their salts. Pharmcomposition based on compound of the formula (I) shows antitumor activity. EFFECT: enhanced effectiveness of compounds synthesized. 27 cl, 2 tbl, 34 ex, 2 dwg