METHOD OF PREPARING GEL-LIKE MATERIAL FOR PLASTICS OF SOFT TISSUES Russian patent published in 1999 - IPC

FIELD: medicinal polymers. SUBSTANCE: gel-like material containing 1.0- 8.0 wt % of acrylamide/methylene-bis-acrylamide copolymer (from 100:0.5 to 100:5.0) and 92.0-99.0 wt % of weakly alkaline water with pH 6.9- 8.5, level of permanganate oxidability up to 1 mgO/l and level of bromination capacity not higher than 3.0 mgBr/l is prepared by copolymerization of acrylamide with methylene-bis-acrylamide in aqueous medium at pH 9.0-9.5 in presence of peroxide polymerization initiator. Reaction mixture is incubated for 2 to 24 hr at 20 to 90 C and then 2-4 hr at 100-105 C. Upon implantation of this material, there is lack of marked inflammatory response and, in later phases, sclerotic phenomena and intergrowth of implant are not observed, while homogeneous structure is preserved. EFFECT: improved biological compatibility. 3 cl, 1 dwg