METHOD OF DIAGNOSING HYPERPLASTIC PROCESSES AND ENDOMETRIUM CANCER Russian patent published in 1999 - IPC

FIELD: oncology. SUBSTANCE: method of differentially diagnosing hyperplastic processes and endometrium cancer is based on quantitative morphodensitometric investigation of alterations in interphase chromatin of nuclei of endometrium glandular cells in patients with hyperplastic processes and endometrium cancer. Method is performed by cytologically analyzing patient's biological material, the latter being endometrium marks obtained by diagnostic scraping of uterine mucous tissue. Material is fixed with special mixture, subjected to ribonuclease treatment, stained with gallocyanin-chrome alum, and placed in Canadian balm. Interphase chromatin of endometrium glandular cells is subjected to microdensitometric analysis and from parameters obtained DF index is calculated as follows: DF=0.00013*CompIOD1+3.98725*C Std OD2+0.00001*IOD+0.01213*PERIMETR- 13.4409. In case of positive index value, endometrium cancer is diagnosed, and, in case of negative one, benign endometrium processes. EFFECT: increased specificity and accuracy of diagnostics. 8 ex