METHOD OF SYNTHESIS OF SUBSTITUTED IMIDAZOLE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to a method of synthesis of intermediate compounds used for synthesis of substituted derivatives of imidazole of the formula (I) where R¹ - phenyl, naphthyl, substituted COO-R³; R² is C₂-C₈-alkyl; R³- is H or C_1-6-alkyl; n = 1. Compounds are synthesized by interaction of compound (II) with compound (III) where X - chlorine, bromine, fluorine or iodine atoms; Y is O-R⁴ where R⁴ is -C_1-6--alkyl in medium of solvent in the presence of a base. Proposed method excludes the use of high pressure and ensures to obtain the end compounds of high purity degree at good yield. EFFECT: improved method of synthesis. 3 cl, 1 ex