FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes new trisubstituted imidazoles of the general formula (I) 
where values R1,R2,R4 are given in p. 1 of the invention claim. Compounds show inhibitory activity with respect to cytokine. Invention describes also a pharmaceutical composition based on compounds of the formula (I), methods of treatment of patients with cytokine-mediated diseases and a method of synthesis of the above indicated compounds. EFFECT: improved method of synthesis and treatment, valuable pharmacological properties. 21 cl
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Year |
Author |
Number |
| 1,4,5-TRISUBSTITUTED IMIDAZOLE DERIVATIVES, METHODS OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
1996 |
- Ehdams Dzherri Leroj
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- Boem Dzheffri Charl'Z
- Sisko Dzhozef
- Li Dzhon Cheung-Lun
|
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1993 |
- Zigfrid Benzhamin Kristensen Iv
|
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1992 |
- Richard Makkallok Kinen
- Dzhozef Vajnshtok
|
RU2124513C1 |
| 6-(SUBSTITUTED METHYLENE)PENEMS, METHOD OF PREPARING THEREOF, INTERMEDIATE PRODUCTS, AND PHARMACEUTICAL COMPOSITION |
1993 |
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|
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1992 |
- Rassell Donovan Kaznz
- Dzhon Dunkan Ehlliott
- Marija Amparo Lago
- Dzhek Dejl Liber
- Kehtrin Ehlizabet Pejshoff
|
RU2125980C1 |
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1993 |
- Mokhamed Kejr Mokallalati
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1993 |
- Dehvid Khej
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|
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| QUINOLINE DERIVATIVES AS TECHYCHININ NK RECEPTOR ANTAGONISTS |
1995 |
- Karlo Farina
- Dzhuzeppe Arnal'Do Maria Dzhardina
- Mario Grun'I
- Luka Franchesko Ravelija
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RU2155754C2 |
| NOVEL COMPOUNDS |
2005 |
- Pinto Ivan Leo
- Rakhman Shakhzad Sharook
- Nikolson Nevill' Kh'Jubert
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RU2395511C2 |
| INDANE, DERIVATIVES, METHOD OF PREPARATION THEREOF, PHARMACEUTICAL COMPOSITION, AND METHOD OF ANTOGONIZATION OF ENDOTHELINE RECEPTORS |
1994 |
- Rassell Donovan Kaznz
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RU2130920C1 |
