FIELD: medicine, more particularly pharmaceutical industry. SUBSTANCE: described are new indane-2-carboxylic acid derivatives o general formula (I): R1,R2,R10,P1,P2,Z1,Z2,Z3 wherein 
are defined in claim 1. Also described are method of preparation thereof, pharmaceutical composition based on compounds of formula (I) and also method of antagonization of endotheline receptors in treating hepertension, kidney insufficiency or cerebrovascular disease using compound of formula (I). EFFECT: improved properties of the pharmaceutical composition. 16 cl, 32 ex
| Title |
Year |
Author |
Number |
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- Kehtrin Ehlizabet Pejshoff
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|
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|
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|
RU2159227C2 |
