DERIVATIVES OF 4-CYANO-4-PHENYLSUBSTITUTED CYCLOHEXANES OR CYCLOHEXENES, PHARMACEUTICAL COMPOSITION (VARIANTS), METHOD OF INHIBITION OF PHOSPHODIESTERASE ACTIVITY AND TUMOR NECROSIS FACTOR Russian patent published in 1999 - IPC

FIELD: organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention describes new derivatives of 4-cyano-4-phenylsubstituted cyclohexanes or cyclohexenes of the formula (I) where R₁ means (CR₄R₅)_r; R₆, where alkyl groups can be optionally substituted with one or more halogen atoms; r = 0-6; R₄ and R₅ are taken independently from hydrogen atom or C_1-2-alkyl; R₆ means hydrogen atom or C_3-6-cycloalkyl where cycloalkyl-group can be optionally substituted with 1-3 methyl groups or a single ethyl group; X means YR₂; Y means O; X₂ means O or NR₈; X₃ means hydrogen atom; X₄ means: (a) or (b); X₅ means H, OR₈ or NR₈R₈; R₂ is taken independently from the group consisting of -CH₃ and -CH₂CH₃ optionally substituted with one or more halogen atoms; S = 0; R₃ means CN, Z-, (5-tetrazolyl), (3- or 5-oxadiazolyl[1,2,4] ), (2-oxadiazolyl-[1,3,4]) being all heterocyclic ring systems can be optionally substituted once or more times with C₁-C₆-alkyl that is optionally substituted with CN; Y′ means O or S; R₇ means C_1-6-alkyl, optionally substituted - CN; R₈ is taken independently from hydrogen atom or C_1-4-alkyl; R₁₀ means R₁₁ where R₁₁ means hydrogen atom or C_1-4-alkyl optionally substituted with one-three fluorine atoms; R₁₄ means hydrogen atom or R₇, or their pharmaceutically acceptable salts. Invention describes also a pharmaceutical composition that inhibits activity of phosphodiesterase-IV and tumor necrosis factor based on the compound of the formula (I) and a method of inhibition of activity of phosphodiesterase-IV and tumor necrosis factor by administration of the above indicated compounds. EFFECT: new compounds indicated above as inhibitors of phosphodiesterase and tumor necrosis factor. 6 cl, 30 ex