PYRAZOLO[1,5-A]PYRIDINES AND PHARMACEUTICAL AGENTS CONTAINING THE SAME Russian patent published in 2007 - IPC C07D471/04 A61K31/437 A61P3/04 A61P3/10 A61P9/00 A61P15/00 A61P19/00 A61P25/08 A61P25/18 A61P25/22 A61P25/24 A61P25/28 A61P35/00 A61P37/08 A61P11/00 A61P43/00 

FIELD: organic chemistry, pharmaceuticals.

SUBSTANCE: invention relates to new chemical compound of general formula I , or salts, or hydrates thereof. In formula I R¹ represents group of formula -G¹-R^1a (wherein G¹ represents single bond, oxygen, sulfur; R^1a represents C₁-C₁₀-alkyl optionally substituted with halogen or C₃-C₈-cycloalkyl); R², R³ and R⁴ are independently hydrogen or -G²⁰-R²⁰ (wherein G²⁰ represents single bond, oxygen, sulfur, sulfinyl or sulfonyl; R²⁰ represents C₁-C₆-alkyl optionally substituted with 1-3 halogen atoms or C₃-C₈-cycloalkyl); R⁵ and R⁶ are independently -X⁵-X⁶-X⁷ group (meanings of X⁵, X⁶ and X⁷ are as defined in specification) or R³ and R⁴ may together form pyrrol ring optionally substituted with C₁-C₆-alkyl; Ar represents phenyl, 1,3-benzodioxolyl, naphthyl, pyridyl, optionally substituted with 1-3 substituents (as defined in specification) Compounds of formula I has antagonistic activity in relates to receptors of corticotrophin releasing factor (CRF). Also disclosed are compounds, characterized by preferable structures, pharmaceutical compositions, using such compounds, intermediates for production thereof and method for treatment of various diseases mediated by CRF.

EFFECT: new compounds as antagonists of CRF receptors.

33 cl, 1 tbl, 316 ex