CYCLOHEXANE DERIVATIVE AND METHOD FOR SLACKING MAMMALIAN UNSTRIPED MUSCLE Russian patent published in 1999 - IPC

FIELD: pharmaceutical chemistry. SUBSTANCE: cyclohexane derivative with general formula I: (I) are provided, where R¹ and R², the same or different, are hydrogen or lower alkyl; R³ optionally substituted heteroaryl; X sulfur atom; and Y group of the following formula: wherein p is 0 or 1 and τ is group of the following formula: -W′-NR⁴-Z′-R⁵ wherein R⁴ is hydrogen or lower alkyl, R⁵ optionally substituted aryl or heteroaryl; Z′ is SO₂ or CO; and W′ group of the following formula: wherein a and x are independently 0 or 1 and R¹⁰ is hydrogen, lower alkyl, or group with formula COCHR¹¹ wherein R¹¹ is hydrogen, lower alkyl, hydroxyalkyl, optionally substituted arylalkyl, optionally substituted carboxyalkyl, or group wherein g is 0 or 1 and K is group W²-NR⁶-Z²-R wherein R⁶ is hydrogen; R⁷ is optionally substituted aryl or heteroaryl; Z² is SO₂ or CO; and W² is group with general formula wherein b is 0 or 1; y=0; t is 0 or 1; and R¹² is hydrogen. EFFECT: enabled prevention and treatment of diseases when opening of calcium canals is important. 8 cl, 1 tbl, 72 ex