FIELD: pharmaceutical chemistry. SUBSTANCE: cyclohexane derivative with general formula I: (I) are provided, where R1 and R2, the same or different, are hydrogen or lower alkyl; R3 optionally substituted heteroaryl; X sulfur atom; and Y group of the following formula:
wherein p is 0 or 1 and τ is group of the following formula: -W′-NR4-Z′-R5 wherein R4 is hydrogen or lower alkyl, R5 optionally substituted aryl or heteroaryl; Z′ is SO2 or CO; and W′ group of the following formula:
wherein a and x are independently 0 or 1 and R10 is hydrogen, lower alkyl, or group with formula COCHR11 wherein R11 is hydrogen, lower alkyl, hydroxyalkyl, optionally substituted arylalkyl, optionally substituted carboxyalkyl, or group
wherein g is 0 or 1 and K is group W2-NR6-Z2-R wherein R6 is hydrogen; R7 is optionally substituted aryl or heteroaryl; Z2 is SO2 or CO; and W2 is group with general formula
wherein b is 0 or 1; y=0; t is 0 or 1; and R12 is hydrogen. EFFECT: enabled prevention and treatment of diseases when opening of calcium canals is important. 8 cl, 1 tbl, 72 ex
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Authors
Dates
1999-04-20—Published
1994-09-20—Filed