AMINO ACID DERIVATIVES Russian patent published in 1999 - IPC

FIELD: organic chemistry, amino acids. SUBSTANCE: invention relates to derivatives of amino acid of the formula (I) where R¹ - hydrogen or acyl; R² - hydrogen, lower alkyl, cycloalkyl, phenyl possibly substituted with alkoxyl, halogen, phenyl or alkylsulfonylamino-group, or thienyl possibly substituted with halogen; m and n = 0, 1 or 2; J - a group of the formulas (A) , (B) , (C) , (D) , (E) where R³ - hydrogen, carboxy-protected group; R⁴ - hydrogen; Y² - a group CH₂, -S- or -O-; R¹⁰ - hydrogen or phenyl; R¹¹,R¹² - hydrogen, lower alkyl; R¹³ - phenyl or a group HSO₂R¹⁸ where R¹⁸ - hydrogen or lower alkyl; R¹⁴,R¹⁵ - hydrogen, or their pharmacologically acceptable salt that show inhibitory activity with respect to angiotensin I-converting enzyme. EFFECT: improved method of synthesis, enhanced inhibitory effectiveness. 33 cl, 10 tbl, 152 ex