SULFONAMIDE DERIVATIVES, METHODS OF THEIR SYNTHESIS, A PHARMACEUTICAL COMPOSITION AND METHOD OF PATIENT TREATMENT Russian patent published in 1999 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention describes new compounds eliciting antitumor activity of the general formula (I): A-W-SO₂N(R′)-B where W means a simple bond, group -CH=CH-; R′ means hydrogen atom or lower alkyl; A means free or substituted aromatic mono- or bicyclic ring, free or substituted nitrogen-, oxygen- or sulfur-containing unsaturated five- or six-membered heterocyclic ring that is noncondensed or condensed with aromatic six-membered ring that can has substituents; B means a substituent of the formulas (II), (III), (IV), (V) or (VI) where each of condensed ring can has substituents. Condition: when A is 4-(acetamido)phenyl or 4-aminophenyl then W means a simple bond; B is not a substituent in formula (VII), or its pharmaceutically acceptable salts. Invention describes a method of synthesis of derivative of sulfonamide of the general formula (I) being B has cyano-group as a substituent. Method of synthesis of compound of the general formula (I) where values W, R′, and A are indicated above and pyrrole ring has a substituent that is able to convert to cyano-group at dehydration involves its interaction with hydrating agent and if necessary protected groups in synthesized compound are removed. Invention describes antitumor agent, a pharmaceutical composition and a method of treatment of patients with tumors using the above indicated compounds of the formula (I). EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 15 cl, 3 tbl