NITROGEN-CONTAINING AROMATIC DERIVATIVES, PHARMACEUTICAL COMPOSITION CONTAINING THEREOF, METHOD FOR TREATMENT AND USING Russian patent published in 2007 - IPC C07D401/12 C07D401/14 C07D403/12 C07D403/14 C07D405/14 C07D409/14 C07D413/14 C07D417/14 A61K31/4439 A61K31/4545 A61K31/506 A61K31/5377 A61P9/10 A61P17/06 A61P19/02 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention describes novel nitrogen-containing aromatic derivatives of the general formula (I): wherein X₁ means nitrogen atom (N) or group -CR₁₀= wherein R₁₀ means hydrogen atom (H), halogen atom or -CN; X₂ means N or group -CR₁₁₌ but X₁ and X₂ can't mean N simultaneously; Y means oxygen atom (O) or group -NR_Y- wherein R_Y means hydrogen atom or (C₁-C₆)-alkyl group; R₁ means phenoxy-group, group -NR_12aR_12b, group , group and other values; each radical among R₃, R₄, R₅, R₆ and R₁₁ means hydrogen atom; R₇ means hydrogen atom or (C₁-C₆)-alkyl group; R₈ means hydrogen atom or (C₁-C₆)-alkyl group; R₁₀ means hydrogen atom, halogen atom or cyano-group; R₉ means group -NR_16aR_16b or group of the formula: wherein T2 means pyrrolidine, piperazine ring possibly substituted with (C₁-C₆)-alkyl group, or morpholine ring; R_12a and R_12b mean independently hydrogen atom, (C₁-C₆)-alkyl, (C₁-C₆)-alkoxy-group; R₂ means hydrogen atom or (C₁-C₆)-alkyl; R_16a means hydrogen atom or (C₁-C₆)-alkyl, and R_16b means (C₁-C₆)-alkyl possibly substituted with phenyl, (C₁-C₆)-alkoxy-group, (C₁-C₆)-alkylthio-group or di-(C₁-C₆)-alkylamino-group, (C₃-C₆)-alkynyl, (C₃-C₈)-cycloalkyl, phenyl possibly substituted with halogen atom, thiazolyl or piperidinyl possibly substituted with (C₁-C₆)-alkyl, and their salts or hydrates. Also, invention describes a pharmaceutical composition, method for treatment or prophylaxis of tumor diseases and using the novel compounds for preparing an agent useful in treatment abovementioned diseases.

EFFECT: valuable medicinal properties of compounds and pharmaceutical composition, improved method for treatment.

26 cl, 17 tbl, 221 ex