INDOLE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS AND A METHOD OF THEIR SYNTHESIS Russian patent published in 1995 - IPC

FIELD: organic chemistry. SUBSTANCE: products: compounds showing inhibiting activity on testosterone-5α-reductase. Indole derivatives of the general formula (I) or their pharmaceutically acceptable salts where R₁ carboxy or protected carboxy-group; R₂ hydrogen, lower alkyl or halogen; R₃ phenyl or mono-, di- or triphenyl (lower) alkyl each of which can has substituent or substituents, or group where means phenoxyazinyl, phenothiazinyl or 10,11-dihydro-5H-dibenzoazepinyl; n 0 or 1; A lower alkylene which can be substituted with oxo, or lower alkenylene; Q carbonyl or lower alkylene; X means a group of the formula (II) or (III) where R₄ hydrogen or lower alkyl; R₅ hydrogen, lower alkyl or Y-Z R₃ where Y bond or lower alkylene; Z lower alkylene, -O- or where R₆ hydrogen, lower alkyl, mono-, di- or triphenyl (lower) alkyl which can has substituent or substituents, or amino-protecting group. EFFECT: improved method of synthesis. 3 cl, 1 tbl