PYRIMIDINE DERIVATIVES AND METHODS OF PREPARING THEREOF Russian patent published in 1999 - IPC

FIELD: pharmaceutical industry. SUBSTANCE: invention describes new pyrimidine derivatives of formula (I-1) and (I-2) wherein R₁ and R₅ are identical or different and are independently hydrogen or C₁-C₃ alkyl group, or taken together, form cyclopentyl or cyclohexyl ring; A is group of formula II: wherein R₁ and R₂ are independently hydrogen or C₁-C₃ alkyl group, and R₃ is hydrogen, C₁-C₃ alkyl group or halogen, and B is 1- (substituted)-1,2,3,4-tetrahydroisoquinolin-2-yl of formula (III-1) or 7-substituted)-4,5,6,7- tetrahydrothieno (2,3-cie)-pyridin-6-yl of formula (III-2), wherein R₆ is hydrogen or C₁-C₃ alkyl group, and pharmaceutically acceptable salts thereof which have superior antisecretory activity with respect to pharmaceutical compositions which comprise active ingredient. Present invention also describes new intermediate compounds and methods of preparing thereof. EFFECT: improved properties of the title compounds. 83 ex, 3 tbl