FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to new aromatic derivatives of carboxylic acid of the formula (I) where R1 means radical of the formula (a) and R2 means C2-8-alkanoyl, C2-8-alkyl, C2-8- -alkenyl, C2-C8-alkynyl or O-CH2R3; or R1 means a residue of the formula (b) and R2 means C2-8-alkanoyl, C2-8-alkenyl, C2-8-alkynyl or O-CH2R3; R3 means C1-6--alkyl, C2-6--alkenyl or C2-6--alkynyl; R4-R9 mean independently each of other hydrogen atom or C1-5-alkyl; or R8 and R9 in combination mean (CRaRb)n; Ra and Rb mean hydrogen atom or C1-5/ -alkyl; n = 1, 2 or 3 and R4-R7 have the above indicated values; or R8 and R9 mean in combination (CRaRb)n and R4 means methylene or ethylene that can be substituted with hydroxyl-group; and Ra,Rb,R5,R7 and n have values indicated above; R10 means carboxyl or C1-6-alkoxy-carbonyl and a dotted bond in formula (a) is optional, and pharmaceutically acceptable carboxylic acid salts of the formula (I). Invention describes also a pharmaceutical composition for therapy and prophylaxis of light and age skin damages and for wound healing on the basis of compound of the formula (I). EFFECT: enhanced therapeutic effectiveness of compounds. 15 cl, 29 ex
Authors
Dates
1999-05-10—Published
1994-09-01—Filed