FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to novel derivatives of substituted urea of the formula (I) 
or their pharmaceutically acceptable salts possessing the retinoid activity, and to pharmaceutical composition and drug based on thereof. In the formula (I) n means a whole number from 0 to 2; X means oxygen atom (O); A-Y means compound of the formula 
; R1 and R3 mean independently of one another hydrogen atom, (C1-C6)-alkyl, (C1-C4)-alkylene-(C1-C4)-alkoxy-group, (C1-C4)-alkylenephenyl optionally substituted with halogen atom, (C1-C4)-alkoxy-, (C1-C4)-alkylenebenzyloxy-, (C1-C4)-alkylenehydroxy-group, (C1-C4)-alkylene (monocyclic heteroaryl comprising 5 ring atoms and one or two heteroatoms chosen from atoms N, O or S) optionally substituted with (C1-C6)-alkyl in ring; R2 means hydrogen atom under condition that R1 doesn't mean hydrogen atom or (C1-C6)-alkyl) if R3 means hydrogen atom.
EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.
12 cl, 10 tbl, 3 sch, 27 ex
