FIELD: organic chemistry, antibiotics. SUBSTANCE: invention relates to a method of producing a crystalline monohydrate form of compound of the formula (I): 
. Method involves a stage of loracarbef form stirring - ethanol crystalline form, acetone crystalline form, dihydrate crystalline form, acetonitrile crystalline form, methanol crystalline form, propanol crystalline form, ethyl acetate crystalline form, methylene chloride crystalline form, bis-(dimethylformamide) crystalline form and mono-(dimethyl- -formamide) crystalline form in water at temperature from about 30 C to about 60 C, preferably at temperature from 40 C to 50 C. Invention relates to also preparing the above indicated crystalline forms by precipitation of compound of the formula (I) as its bis-(dimethylformamide) solvate form in the corresponding solvent. EFFECT: improved method of producing. 8 cl, 1 tbl, 6 ex
| Title |
Year |
Author |
Number |
| METHOD OF PREPARING CRYSTALLINE LORACARBEF MONOHYDRATE FROM CRYSTALLINE LORACARBEF DIHYDRATE |
1994 |
- Ehdvard Frensis Plokharchik
- Ehrin Ehkert Strouz
|
RU2124013C1 |
| CRYSTALLINE ANHYDROUS FORM OF LORACARBEF AND METHOD OF PREPARING LORACARBEF MONOHYDRATE (VARIANTS) |
1996 |
- Vill'Jam Karl Khenning
- Teodor R. Staut
|
RU2160261C2 |
| BICYCLIC COMPLEXES BETA-LACTAM/HYDROXYBENZOIC ACID, METHODS OF BETA-LACTAMS SYNTHESIS |
1994 |
- Dzhejn Godde Amos
- Dzhozef Majkl Indelikato
- Kehrol Ehlejn Pasini
- S'Juzn Mehri Rojtsel'
|
RU2134265C1 |
| METHOD OF SYNTHESIS OF CRYSTALLINE FORM OF MONO- (N,N′ -DIMETHYLFORMAMIDE) -1- CARBOCEPHALOSPORIN DIHYDRATE SOLVATE |
1990 |
- Tomas Majkl Ehkrich[Us]
- Richard Charl'Z Khojing[Us]
|
RU2028298C1 |
| 3,4,4-TRISUBSTITUTED PIPERIDINYL-N-ALKYLCARBOXYLATES AND INTERMEDIATE COMPOUNDS, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION |
1994 |
- Skott Alan Frehnk
- Duglas Ehdvard Preter
- Dzheffri Alan Uord
- Dzhon Arnol'D Verner
|
RU2145958C1 |
| ACETONE, 1-BUTANOL, 1-PROPANOL OR 2-PROPANOL SOLVATES OF DIRYTHROMYCIN, CRYSTALLINE ACETONE, 1-BUTANOL, 1-PROPANOL OR 2-PROPANOL SOLVATES OF DIRYTHROMYCIN, PURIFIED FORM II OF DIRYTHROMYCIN, METHOD OF PREPARING DIRYTHROMYCIN FORM II, METHOD OF ISOLATION OF DIRYTHROMYCIN FORM II, METHOD OF SOLVATE PREPARING |
1992 |
- Dzhejms Majkl Grin[Us]
- Kholli Mari Khehnkins[Us]
- Gregori Alan Stehfenson[Us]
- Dehvid Dehjl Virt[Us]
|
RU2070203C1 |
| PIPERIDINE COMPOUNDS AND PHARMACEUTICAL COMPOSITION SHOWING ACTIVITY AS ANTAGONIST OF OPIOID PERIPHERAL ACTION |
1992 |
- Baddi Judzhin Kantrell[Us]
- Dennis Majkl Tsimmerman[Us]
|
RU2076863C1 |
| MACROCYCLIC BIS-INDOL MALEIMIDE DERIVATIVES, METHOD OF PREPARATION THEREOF (VARIANTS) AND PHARMACEUTICAL COMPOSITION |
1994 |
- Vill'Jam Frehnsis Khit
- Majkl Robert Dzhirosek
- Dzhon Khehmpton Makdonal'D Iii
- Kristofer Dzhon Rito
|
RU2147304C1 |
| METHOD OF SYNTHESIS OF (S)--1÷1-N,N-DIMETHYL-3-(1-NAPHTHALINYL- -HYDROXY)-3-(2-THIENYL)-PROPANEAMINE AND (S)-±-N,N-DIMETHYL- -3-(1-NAPHTHALINYLHYDROXY)-3-(2-THIENYL)-PROPANEAMINE PHOSPHATE |
1994 |
|
RU2127269C1 |
| ANTIBIOTIC BASED ON CRYSTALLINE MONOHYDRATE FORM OF 1-CARBOCEPHALOSPORIN |
0 |
|
SU1731058A3 |
