METHOD OF PRODUCING CRYSTALLINE MONOHYDRATE FORM OF β-LACTAM Russian patent published in 1999 - IPC

Abstract RU 2130456 C1

FIELD: organic chemistry, antibiotics. SUBSTANCE: invention relates to a method of producing a crystalline monohydrate form of compound of the formula (I): . Method involves a stage of loracarbef form stirring - ethanol crystalline form, acetone crystalline form, dihydrate crystalline form, acetonitrile crystalline form, methanol crystalline form, propanol crystalline form, ethyl acetate crystalline form, methylene chloride crystalline form, bis-(dimethylformamide) crystalline form and mono-(dimethyl- -formamide) crystalline form in water at temperature from about 30 C to about 60 C, preferably at temperature from 40 C to 50 C. Invention relates to also preparing the above indicated crystalline forms by precipitation of compound of the formula (I) as its bis-(dimethylformamide) solvate form in the corresponding solvent. EFFECT: improved method of producing. 8 cl, 1 tbl, 6 ex

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RU 2 130 456 C1

Authors

Robert Luis Nist

Marvin Ehmanjuehl' Vil'Dfejer

Dates

1999-05-20—Published

1994-06-03—Filed