METHOD OF SYNTHESIS OF (S)--1÷1-N,N-DIMETHYL-3-(1-NAPHTHALINYL- -HYDROXY)-3-(2-THIENYL)-PROPANEAMINE AND (S)-±-N,N-DIMETHYL- -3-(1-NAPHTHALINYLHYDROXY)-3-(2-THIENYL)-PROPANEAMINE PHOSPHATE Russian patent published in 1999 - IPC

FIELD: organic chemistry, chemical technology, pharmaceutical chemistry. SUBSTANCE: invention relates to asymmetric process of synthesis of key intermediate compound used for synthesis of antidepressant agent dulonectin. Method of synthesis of the above indicated compound involves interaction of (S)-(-)- -N, N-dimethyl-3-(2-thienyl)-3-hydroxypropaneamine with sodium hydride and 1-fluoronaphthalene in an organic solvent. Process is carried out using potassium benzoate or acetate and the end product is isolated as a free form or if necessary as phosphate. EFFECT: accelerated process, enhanced purity, increased yield of the end product. 6 cl, 2 ex