ACETONE, 1-BUTANOL, 1-PROPANOL OR 2-PROPANOL SOLVATES OF DIRYTHROMYCIN, CRYSTALLINE ACETONE, 1-BUTANOL, 1-PROPANOL OR 2-PROPANOL SOLVATES OF DIRYTHROMYCIN, PURIFIED FORM II OF DIRYTHROMYCIN, METHOD OF PREPARING DIRYTHROMYCIN FORM II, METHOD OF ISOLATION OF DIRYTHROMYCIN FORM II, METHOD OF SOLVATE PREPARING Russian patent published in 1996 - IPC

FIELD: antibiotics. SUBSTANCE: product: acetone, 1-butanol, 1-propanol or 2-propanol diryhthromycin solvate consisting of 1 solvent molecule and one molecule of dirythromycin, and purified form II of dirythromycin exhibiting the following powder X-ray photograph: d - 14.17; 11.96; 10.43; 9.65; 8.86; 8.18; 7.07; 6.99; 8.84; 6.59; 6.24; 6.07; 5.97; 5.77; 5.54; 5.50; 5.45; 5.13; 5.11; 4.84; 4.75 and d - 4.72; 4.50; 4.44; 4.24; 4.20; 4.11; 4.09; 3.92; 3.87; 3.83; 3.73; 3.55; 3.46; 3.42; 3.33; 3.17; 3.11; 2.96; 2.83; 2.74; 2.57. Form II is prepared by suspending indicated solvates in nonaqueous solvent containing from 40% to 100% water being solvent corresponds to desired solvate, or dirythromycin form II is suspended in n-heptane, n-octane, ethyl acetate containing 80-100% water. Solvate is prepared by contacting dirythromycin with desired solvent containing 0-80% water. EFFECT: improved method of solvates preparing. 1 tbl