FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes the novel crystalline ester of (αS, 3R, 4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-α-(phenyl- -methyl)-1-piperidine propionic acid of the formula 
where R is C1-C6-alkyl; Z - the group taken among hydrochloride, hydrobromide, succinate and (+)-dibenzoyl tartrate that can be used for binding the specific receptor in patient. Compound is used for treatment of patients with irritable bowel syndrome, idiopathic constipation and nonulcer dyspepsia. EFFECT: improved method of synthesis, valuable pharmacological properties. 12 cl, 9 tbl, 8 ex
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1992 |
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RU2076863C1 |
| BENZOTHIOPHENE COMPOUNDS OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS |
1996 |
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| NAPHTHYL DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND INTERMEDIATE SUBSTANCES |
1996 |
|
RU2167849C2 |
| METHOD FOR MINIMIZATION OF HYSTEROTROPHIC EFFECT OF TAMOXYPHENE AND ANALOGS THEREOF |
1995 |
- Genri Ul'Man Brajant
- Stiven Ehntoni Fontana
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RU2158589C2 |
| DERIVATIVES OF NAPHTHALENE AND DIHYDRONAPHTHALENE, PHARMACEUTICAL COMPOSITION BASED ON THEREOF, METHODS OF TREATMENT AND INTERMEDIATES SUBSTANCES |
1996 |
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| NAPHTHYL-CONTAINING COMPOUNDS, PHARMACEUTICAL COMPOSITION, METHOD OF ATTENUATION OF POSTCLIMACTERIC SYNDROME SYMPTOMS AND OTHER ESTROGEN-ASSOCIATED PHYSIOLOGICAL STATES, METHODS OF SYNTHESIS OF NAPHTHYL-CONTAINING COMPOUNDS |
1995 |
- Genri Ul'Man Brajant
- Dzhordzh Dzhozef Kallinan
- Dzheffri Alan Dodzh
- Kennan Dzhozef Fejkhi
- Charl'Z Dehvid Dzhounz
- Charl'Z Villis Lugar Iii
- Brajan Stefen Mjul'
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RU2165924C2 |
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1993 |
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RU2107067C1 |
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1994 |
- Dzhordzh Dzhozef Kallinan
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RU2132682C1 |
| METHOD OF SYNTHESIS OF 2-SUBSTITUTED BENZO[B]THIOPHENE (VARIANTS), METHOD OF SYNTHESIS OF DERIVATIVES OF 2-PHENYL-3-AROYLBENZO[B]THIOPHENE (VARIANTS) AND DERIVATIVES OF BENZO[B]THIOPHENE |
1996 |
- Kennet L.Khoser
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RU2147582C1 |
| USE OF 6-HETEROCYCLO-4-AMINO-1,3,4,5-TETRAHYDROBENZ[CD]INDOLE USED IN VOMITING OR NAUSEA AT MOVING, PHARMACEUTICAL COMPOSITION |
1993 |
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