FIELD: organic chemistry, pharmacy. SUBSTANCE: risperidone pamoate of the formula (I) 
is synthesized by treatment of 3-[2-[4- -(6-fluoro-1,2-benzisoxazole-3-yl)-1-piperidinyl] ethyl]- -6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidine-4-one with pamoic acid in an inert solvent. Compounds of the formula (I) provide the prolonged release from low water-soluble pamoates. These compounds are dopamine antagonists exhibiting the prolonged effect. EFFECT: improved method of synthesis, prolonged antipsychotic activity. 9 cl, 1 tbl, 2 ex
| Title |
Year |
Author |
Number |
| 2,9-DISUBSTITUTED 4H-PYRIDO-(1,2-A)-PYRIMIDINE-4-ONES AND ANTIPSYCHOTIC COMPOSITION |
1991 |
- Ljudo Ehdmond Zhozefin Kennis[Be]
- Jan Vandenberk[Be]
- Al'Bertus Khendrikus Marija Terezija Van Khehrtum[Be]
|
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1994 |
- Jan Vandenberk
- Ljudo Ehdmon Zhozefin Kenni
|
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| RISPERIDONE-CONTAINING MICROCAPSULES, PHARMACEUTICAL COMPOSITION AND METHODS OF THEIR MAKING |
1994 |
- Mesens Zhan-Lui
- Riki Majkl E.
- Atkins Tomas Dzh.
|
RU2178695C2 |
| METHOD FOR PREPARATION OF 3-PIPERAZINYLBENZAZOL DERIVATIVES OR THEIRS PHARMACEUTICALLY ACCEPTABLE ADDITIVE SALTS |
0 |
- Lyudo Edmond Zhozefin Kennis
- Yan Vandenbek
- Zhozefus Karolus Mertens
|
SU1687030A3 |
| AQUEOUS RISPERIDONE COMPOSITIONS |
1995 |
- Mark Karel Jozef Fransua
- Villi Marija Al'Bert Karlo Dris
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| USE OF CYCLODEXTRIN AS MUCOADHESIVE AGENT, COMPOSITION BASED ON INTRACONAZOL AND CYCLODEXTRIN AND METHOD OF ITS PREPARING |
1995 |
- Peter Putteman
- Mark Karel Jozef Fransua
- Ehrik Karolus Leonarda Snuks
|
RU2164418C2 |
| METHOD OF PRODUCING DERIVATIVES OF 1,2-BENZISOXAZOLYL-3, OR 1,2-BENZISOTHIAZOLYL-3 OR STEREOSIOMERS THEREOF OR ACID-ADDITIVE SALTS THEREOF |
0 |
- Lyudo Edmon Zhozefin Kennis
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|
SU1468419A3 |
| SUBSTITUTED DIHYDROPYRANOPYRIDINES, METHOD OF THEIR SYNTHESIS, INTERMEDIATE COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHOD OF ITS PREPARING |
1994 |
- Gi Rozalia Ehzhen Van Lommen
- Fransisko Khav'Er Fernandes-Gadea
- Khose Ignasio Andreskhil'
- Marija Ehnkarnas'On Matesans-Ballesteros
|
RU2135501C1 |
| IMIDAZOAZEPINE DERIVATIVE, PHARMACEUTICAL COMPOSITION, METHOD OF ITS PREPARING, METHOD OF SYNTHESIS OF IMIDAZOAZEPINE DERIVATIVE |
1994 |
- Frans Ehduard Zhansens
- Jozef Ehlizabet Lehnarts
|
RU2133249C1 |
| SABELUZOL AQUEOUS SUSPENSION FOR ORAL USE AND METHOD OF ITS PREPARING |
1995 |
- Mark Karel Jozef Fransua
- Kristin Frida Ogjusta Agemans
|
RU2141821C1 |
