FIELD: medicine. SUBSTANCE: described in new 6-(substituted methylene)penem of general formula I wherein R2 is condensed bicyclic heterocyclic system of rings of general formula II wherein m is 2 or 3; p is 0, 1 or 2; and R3 is hydrogen, salt-forming cation or pharmaceutically acceptable ester hydrolyzable in vivo, symbol =/= shows that double bond is either in E or Z configuration. Described are pharmaceutical composition based on compounds of formula I having beta-lactamase inhibiting activity and method of inhibiting beta- lactamase in treating bacterial infections in man and animals. EFFECT: improved properties of the pharmaceutical composition. 17 cl, 9 ex, 1 tbl
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