2,3-DIHYDRO-6-NITROAMIDAZO [2,1-b] OXAZOLE DERIVATIVES Russian patent published in 2008 - IPC C07D498/04 C07D498/20 C07D519/00 C07F7/10 A61K31/424 A61K31/454 A61K31/4545 A61K31/4709 A61K31/496 A61K31/498 A61K31/4245 A61K31/4439 A61K31/497 A61K31/428 A61K31/4725 A61K31/438 A61K31/551 A61K31/5377 A61K31/506 A61K31/695 A61K31/46 A61P31/06 

Abstract RU 2326121 C2

FIELD: chemistry.

SUBSTANCE: invention proposes a 2,3-dihydro-6-nitroamidazo[2,1-b]oxazole derivative, with the following general formula (1) , where R1 represents a hydrogen atom or a C1-6alkene group, n is an integer from 0 to 6, R2 represents a OR3 group or similar, and R3 represents a hydrogen atom, C1-6alkene group or similar. R1 and -(CH2)nR2 can be interlinked with adjacent carbon atoms through nitrogen atoms, with formation of a spiro-ring, represented by general formula (H) , where R41 represents a hydrogen atom, C1-6alkene group or similar.

EFFECT: given compound has bactericidal action against Mycobacterium tuberculosis, multi-resistant to medication for Mycobacterium tuberculosis and atypical acid-fast bacteria.

48 cl, 119 tbl, 1885 ex

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RU 2 326 121 C2

Authors

Tsubouti Khidetsugu

Sasaki Khirofumi

Kuroda Khideaki

Itotani Motokhiro

Khasegava Takesi

Kharaguti Josikazu

Kuroda Takesi

Matsuzaki Takajuki

Tai Kuninori

Komatsu Makoto

Matsumoto Makoto

Khasizume Khirojuke

Tomisige Tatsuo

Sejke Judzi

Kavasaki Masanori

Sumida Takumi

Mijamura Sin

Dates

2008-06-10Published

2003-10-10Filed