METHOD OF EVALUATION OF PATIENT'S STATE IN ENDOPROSTHETICS OF ARTICULATIONS Russian patent published in 1999 - IPC

FIELD: medicine; may be used in clinical practice for evaluation of patient state and adoption of decision on indications for operation for endoprosthetics of articulations and also for prognosis of complications and analysis of course of postoperative period. SUBSTANCE: method is based on blood analyses during preoperative and postoperative periods. Method includes determination of content of immunoglobulins of G and M classes and activity value of natural killer cells; level of lipoperoxidation by content of malonic dialdehyde; rate of migration of lymphocytes and rate of inhibition of lymphocyte migration under the effect of nonspecific mitogen. With normal ratio of the values, expediency of performance of operation for endoprosthetics of articulations is determined. In this case, considered as normal value is content of class G immunoglobulin amounting to 8-18 mg/ml, content of class M immunoglobulin equalling 0.6-2.5 mg/ml, value of activity of natural killer cells being equal to or less than 20% of destruction, level of lipoperoxidation by content of malonic dialdehyde being less than 0.2-0.5 arbitrary units; rate of granulocyte migration being 1.8-4.0 arbitrary units, rate of monocyte migration being 2.3-5.0 arbitrary units, rate of granulocyte inhibition reaction under the effect of nonspecific mitogen being +(31-79)%, rate of inhibition reaction of monocyte migration under the effect of nonspecific mitogen being +(29-59)%. During postoperative period blood analyses are performed repeatedly with determination of dynamic relationship of the values variation. With detected tendency for normalization of the values, noncomplicated outcome of operation is prognosticated. Should values of rate of granulocyte inhibition reaction be equal to or less than 0% in combination with stable deviation from standards of values of activity of natural killer cells and level of lipoperoxidation, and/or with reduced value of class G immunoglobulin, possibility of serious postoperative complications are prognosticated. The method is realized under conditions of equipment of clinics with modern laboratory analytic facilities, and it features high prognostic value. EFFECT: higher efficiency. 2 cl, 3 dwg, 1 tbl