FIELD: medicine. SUBSTANCE: D3 vitamin analogs of formula I: H2 wherein R is H, OH or F; X is CH2 or 
, and double bond has E- or Z-configuration. Pharmaceutical drug containing effective amount of compound I has stimulating differentiation which reduces proliferation of human caratinocytes and antitumor activity. EFFECT: improved properties of the drug. 7 cl, 3 dwg, 15 ex, 4 tbl
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