MORPHINANE O-ARYL ESTERS, PHARMACEUTICAL COMPOSITION Russian patent published in 1998 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to morphinane O-aryl esters of the general formula (IA) where R^2′ is free or substituted pyridyl, thiazolyl, thienyl, phenyl or a group of the formula ; R²⁰ is H, alkyl or a group R^1′ where one of Y and C(Y,Y¹)-CH₂OH is H and other alkyl, or both Y and Y¹ are alkyls at condition that when Y¹ is pyridyl or R^2′ phenyl then R^1′ can not be alkyl, or their pharmaceutical salts. Compounds of the formula (IA) decrease unwanted effect of neurotoxic damage and therefore they can be used for treatment of patients with convulsions and neuroinhereted sicknesess. EFFECT: improved method of synthesis, enhanced effectiveness of compounds.