FIELD: medicine, pharmacy. SUBSTANCE: invention relates to drugs, a combined preparation, a pharmaceutical composition and a method for prophylaxis or treatment of inflammatory states or analgesia. Drug for treatment or prophylaxis of damage of gastroenteric tract caused by nonsteroid anti-inflammatory drugs is ranitidine bismuth-citrate or a pharmaceutical composition containing its. Combined preparation for treatment or prophylaxis of inflammatory states or for analgesia in human or animals has an effective amount of nonsteroid anti-inflammatory drug and an effective amount of the claimed drug. It is adopted for providing the simultaneous, separated or successive administration of indicated drugs. A pharmaceutical composition is made in the form for oral use and has nonsteroid anti-inflammatory drug, claimed drug and pharmaceutically acceptable carriers or filling agents. Claimed drug in the composition is taken at effective amount for prophylaxis of gastroenteric tract damage. Method of prophylaxis or treatment of inflammatory states or analgesia in human and animals involves administration of nonsteroid anti-inflammatory drug taken at effective amount and the claimed drug at effective amount is administrated before, after or simultaneously with nonsteroid anti-inflammatory drug. EFFECT: significant decreased degree of damage of gastroenteric tract mucosa. 16 cl, 1 tbl, 3 ex
