SALMETEROL XINAFOATE EXHIBITING CONTROLLED PARTICLE SIZE AND PHARMACEUTICAL COMPOSITION Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes a new compound - 1-hydroxy-2-naphthalenecarboxylate of 4-hydroxy-α′-[[[6-(4-phenylbutoxy)hexyl] amino] methyl]-1,3-benzenedimethanol (salmeterol xinafoate) as easily fluidized crystalline form and exhibiting controlled particle size from 1 to 10 microns and dynamic volume density less 0.1 g x cm^-3 that can be used for preparing a pharmaceutical compound with an acceptable carrier. Invention describes also a pharmaceutical composition that can be used for inhalation and containing the above indicated compound. The composition is easy for using and can be fluidized easily. EFFECT: improved quality and properties of the composition. 9 cl, 48 dwg, 6 tbl, 14 ex