FIELD: chemistry.
SUBSTANCE: invention claims an improved method for obtaining flutixasone propionate in the form of polymorphous Form 1, which involves reaction of compound of the formula (II) 
or its salt with compound of the formula LCH2F, where L is a leaving group, possibly in the presence of interphase transfer catalyst, organic non-solvating fluid solvent non-mixable with water, and water.
EFFECT: chances to carry out crystal polumorphous fluticasone propionate obtaining process at normal air pressure and without extraction of transition product.
11 cl, 14 dwg
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