SPECIFIC GLYCOCOTRICOSTEROID COMPOUND WITH ANTIINFLAMMATORY EFFECT Russian patent published in 2009 - IPC C07J3/00 C07D233/14 A61P37/08 A61K31/56 A61P5/44 

Abstract RU 2348645 C2

FIELD: chemistry.

SUBSTANCE: invention claims compound of formula (I) , where X is O or S; R1 is C1-6alkyl, C3-8cycloalkyl, C3-8cycloalkylmethyl, any of which can be optionally substituted by one or more methal groups or halogen atoms, or R1 is 4-(diethylamino)sulfonylphenyl, 2,6-difluorophenyl, 4-methoxyphenyl, 4-cyanomethyl, 3-difluoromethylthiopnehyl, 5-chloro-4-methoxy-thiophene-3-yl, 2-isopropyl-1,3-thiazol-4-yl, quinoline-2-yl, 5-trifluoromethyl-furan-2-yl, 5-methylsulfonyl-thiophene-2-yl, 5-methylthio-thiophene-2-yl, or 5-ethylisoxazene-2-yl; R2 is hydrogen, methyl which can be either in α- or β-configuration; R3 and R4 are the same or different, each is independently hydrogen, halogen, and is simple or double link; or its pharmaceutically acceptable salt or solvate.

EFFECT: obtaining compound with glycocorticosteroid effect.

20 cl, 25 ex

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RU 2 348 645 C2

Authors

Biggadajk Kejt

Dzhon Meht'Ju Piter

Nidkham Debora

Dates

2009-03-10Published

2004-07-09Filed