FIELD: synthesis of biologically-active compounds. SUBSTANCE: invention relates to new biologically-active annealed dihydropyridine derivatives and more specifically to isoquinoline derivatives and their salts with following formula: 
(I) where R1 and R2, independently, are hydroxyl, C1-C4-alkoxy, halogen, C1-C4-alkyl, or benzyloxy group; B group - O- , -S- or group CHR5 in which R5 is hydrogen or C1-C6-alkyl; R3 is 2- or 3-thienyl, C4-C7-cycloalkyl, or group with formula 
wherein R6 is halogen or C1-C4-alkoxy and u= 0,1 or 2; R4 is optionally phenyl- substituted C3-C6-alkenyl, C1-C13-alkyl optionally substituted by a substituent selected from group including thienyl, adamantyl, cyclohexyl, benzyloxy, phenoxy, and phenyl, the latter or phenyl contained in phenoxy group being optionally mono-, di- and trisubstituted by a substituent selected from group including hydroxyl, C1-C4-alkoxy, halogen, trifluoromethyl, nitrogen dioxide, and C1-C4-alkyl or substituted by two phenyl groups; and radicals having following formulas: 
wherein R7 is halogen, trifluoromethyl, or nitrogen dioxide, and v=0,1, or 2; and their salts with physiologically tolerable acids. When tested on microcultures of various human tumor cell lines carried out with the aid of so called tetrazolium assay, substances manifested high antiproliferative activity as compared with known verapamilum. EFFECT: achieved high antitumor activity. 4 cl, 2 tbl, 48 ex
