HETEROCYCLIC NITROGEN CONTAINING COMPOUNDS AS RACEMATES OR INDIVIDUAL ENANTIOMERS WHICH ARE LEUKOTRIENE BIOSYNTHESIS INHIBITORS Russian patent published in 1997 - IPC

FIELD: organic chemistry. SUBSTANCE: claimed invention describes heterocyclic nitrogen containing compounds of formula I: $$$ wherein X is oxygen or sulfur; Y is carbon or nitrogen; Z is carbon or nitrogen, Y and Z simultaneously are not nitrogen; $$$ and $$$ are independently hydrogen, alkyl containing 1 to 6 carbon atoms, halogen, trifluoromethyl, nitrile, alkoxy containing 1 to 6 carbon atoms, $$$ wherein $$$ is hydrogen or alkyl containing 1 to 6 carbon atoms, $$$ wherein $$$ and $$$ are independently hydrogen, alkyl containing 1 to 3 carbon atoms, methoxy or together with nitrogen form morphiline, pyrrolidine or piperidino, $$$ wherein $$$ and $$$ are hydrogen or alkyl containing 1 to 6 carbon atoms, $$$ wherein $$$ is alkyl containing 1 to 6 carbon atoms.$$$ wherein is as defined above, $$$ wherein $$$ is as defined above. $$$ wherein $$$ is as defined above, and $$$ wherein $$$ and $$$ are independently hydrogen or alkyl containing 1 to 6 carbon atoms; $$$ is methyl, cyclohexyl, phenyl, unsubstituted or substituted with residues of group consisting of halogen, trifluoromethyl, alkyl containing from 1 to 4 carbon atoms and alkoxy containing 1 to 4 carbon atom; $$$ wherein $$$ is as defined above, $$$ wherein $$$ is as defined above, $$$ wherein $$$ is as defined above wherein $$$ and $$$ are as defined above, nitro, 1- piperidinyl, 2-, 3- or 4-pyridine, morpholine, thiomorphaline, pyrrolidine, imidazole unsubstituted or substituted at nitrogen with alkyl containing 1 to 4 carbon along, 2-thiazole, 2-methyl-4-thiazole, dialkylamine containing 1 to 4 carbon atoms in each alkyl group or alkyl ether containing 1 to 4 carbon atoms; $$$ is ester of formula wherein $$$ is alkyl containing 1 to 4 carbon atoms; $$$ is ester of formula wherein $$$ is alkyl containing 1 to 4 carbon atoms, amide of formula: $$$ wherein $$$ and $$$ are independently hydrogen, alkyl containing 1 or 2 carbon atoms, methoxy or together with nitrogen form morpholine, piperidine or pyrrolidine, phenyl unsubstituted or substituted with residues of group consisting of halogen, alkyl containing 1 to 4 carbon atoms and alkoxy containing 1 to 4 carbon atoms, 3 methyl-1,2,4-oxadiazol-5-yl, 2-or 3-thienyl, 2-, 3- or 4- pyridyl, 4-pyrazolyl, 2-imidazole unsubstituted or substituted in position 4 with methyl; ketone of formula: $$$ wherein $$$ is alkyl, containing 1 to 3 carbon atoms, phenyl or 1-methylimidazol-2yl, ether of formula: $$$ wherein $$$ is alkyl containing 1 to 3 carbon atoms, thioether of formula wherein $$$ is as defined above. $$$, amine of formula: $$$ wherein $$$ is as defined above, residue of formula: $$$ wherein $$$ is methyl, amino or methylamino, $$$ wherein Me is methyl or carbamate of formula: $$$, $$$ and $$$ are independently hydrogen or methyl; n is 0, 1 or 2, provided that said substituents are not defined as Y and Z are carbon, $$$ and $$$ are hydrogen, halogen, alkyl containing 1 to 4 carbon atoms, alkoxy containing 1 to carbon atoms, cyano, nitro, trifluoromethyl; $$$ is unsubstituted phenyl and $$$ is $$$ wherein $$$ is hydrogen, alkyl, alkenyl or alkynyl, $$$ wherein $$$ and $$$ are hydrogen, alkyl containing 1 to 6 carbon atoms, phenyl, alkoxy or together with nitrogen form pyrrolidine or morpholine, cyano or $$$ or Y and Z are carbon; $$$ is $$$; $$$ and $$$ are hydrogen and $$$ is hydrogen and $$$ is 4- oxyphenyl unsubstituted phenyl and 4-imidazol as racemates or individual enantiomers and salts thereof which are lenkotriene bioxynthesis inhibitors. EFFECT: improved properties of the title compounds. 18 tbl