FIELD: biologically-active compounds. SUBSTANCE: pyridazine[4',5':3,4] pyrrolo[2,1-a]isoquinoline derivatives with general formula 1: (1), where X is oxygen or sulfur atom or NHO group; R1 is C1-10-alkyl optionally substituted by phenoxyl or phenyl; and R2 and R3 are alkoxy radicals, and their physiologically acceptable salts are suitable as cardio- and cephalloprotectors. EFFECT: increased choice of hearth and brain drugs. 11 cl, 2 tbl, 3 ex
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