METHOD OF PREPARING 5-(1,2,4-TRIAZOL-1-YL)TRIPTAMINE COMPOUNDS, AND 2-[5- (1,2,4-TRIAZOL-1-YL)-1H-INDOL-3-YL]ETHANOL Russian patent published in 1999 - IPC

Abstract RU 2138496 C1

FIELD: organic synthesis. SUBSTANCE: N,N-dimethyl-2-[5-(1,2,4-triazol-1-yl-methyl)-1H-indole- 3-yl]ethylamine (formula I: ) is prepared by interaction of 2-[5-(1,2,4- triazol-1-yl)-1H-indol-3-yl] ethanol with methansulfonyl chloride at -20 C in dry tetrahydrofuran followed by treating intermediate methansulfonate with 40% aqueous dimethylamine. EFFECT: avoided conventionally utilized triphenylphosphine and lithium chloride and eliminated triazolyl polymerization tendency. 11 cl

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RU 2 138 496 C1

Authors

Cheng J.Chen

Robert D.Larsen

Tomas R.Verkhoehven

Dates

1999-09-27Published

1995-05-19Filed