FIELD: medicine. SUBSTANCE: described are new 2,3-dehydro-1-(2,2,2-trifluoroethyl)-2-oxo-5-phenyl- 1H-1,4-benzodiazepines of general formula I: wherein X and Y are independently hydrogen, chlorine or trifluoromethyl, and n is 0,1 or 2; R is hydrogen or fluorine; and their mixtures of enantiomers, individual diastereomers or individual enantiomers with all isomeric forms, and pharmaceutically acceptable salts, hydrates or crystalline forms thereof, which are antirythmic agents. Also described are methods of prevention of treatment of arythmia. EFFECT: improved properties of the title compounds. 5 cl, 19 ex, 1 tbl
Title |
Year |
Author |
Number |
DERIVATIVES OF DIAZEPINE, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT OF PATIENTS WITH ARRYTHMIA |
1994 |
- Dzhon Dzh. Boldvin
- Dehvid A. Klehrimon
- Dzhejson M. Ehlliot
- Nigel Liverton
- Dehvid K. Remi
- Garol'D G. Selnik
|
RU2155587C2 |
DERIVATIVES OF HEXAHYDRODIAZEPINONE, PHARMACEUTICAL COMPOSITION CONTAINING THEREOF AND USING IN PREPARING MEDICINAL AGENT FOR TREATMENT OF NON-INSULIN DEPENDENT DIABETES MELLITUS |
2003 |
- Biftu Tesfaje
- Ljang Guj-Baj
- Tsjan' Sjaosja
- Uehber Ehnn Eh.
- Fehn Dantsin Dennis
|
RU2301803C2 |
SUBSTITUTED HETEROCYCLES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALT, PHARMACEUTICAL COMPOSITION FOR BLOCKADE OF NEUROKININ-1 RECEPTORS IN MAMMALS, METHOD OF BLOCKADE OF NEUROKININ-1 RECEPTORS IN MAMMALS |
1993 |
- Konrad P.Dorn
- Dzheffri Dzh.Khejl
- Mal'Kol'M Mehkkoss
- Sander Dzh.Millz
- Tamara Lehdduvakhetti
- Shrenik K.Shakh
|
RU2140914C1 |
SUBSTITUTED MORPHOLINES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF COUNTERACTION TO SUBSTANCE P OR INHIBITION OF NEUROKININ-1 RECEPTORS |
1995 |
- Konrad P. Dorn
- Dzheffri Dzh. Khejl
- Mal'Kol'M Makkoss
- Sander G. Mills
|
RU2170233C2 |
METHOD OF TREATMENT OF PATIENTS WITH PROSTATE BENIGNITY HYPERPLASIA, PHARMACEUTICAL PREPARATION CONTAINING INHIBITOR OF 5-ALPHA-REDUCTASE |
1992 |
- Glenn Dzh.Gomlej
- Ehlizabet Stoner
|
RU2125879C1 |
NOVEL HETEROCYCLIC COMPOUNDS AND USE THEREOF IN MEDICINE AND COSMETICS |
2015 |
- Fournier Jean-Francois
- Clary Laurence
- Thoreau Etienne
|
RU2712971C2 |
CGRP RECEPTOR ANTAGONISTS |
2004 |
- Bergi Kristofer S.
- Dehn Chzhehnu Tsz
- Ngujen Dim N.
- Pehuan Dehniel V.
- Sho Ehntoni U.
- Uill'Jams Tereza M.
|
RU2308458C2 |
1,1,2,2-TETRA (HETERO) ARYLETHANES OR 1,1,2-TRI (HETERO) ARYL-2-HETEROCYCLYLETHANES AS POTASSIUM CHANNEL INHIBITORS |
2005 |
- Bilodo Mark T.
- U. Chzhitsaj
- Khartnett Dzhon
|
RU2344134C2 |
BENZOXAZINONES AND PHARMACEUTICAL COMPOSITION COMPRISING THEREOF FOR INHIBITION OF ACTIVITY OF HIV REVERSE TRANSCRIPTASE, TREATMENT AND PROPHYLAXIS OF AIDS AND ARS, METHOD OF INHIBITION OF ACTIVITY OF HIV REVERSE TRANSCRIPTASE, METHOD OF PROPHYLAXIS OF HIV INFECTION, TREATMENT OF HIV AND ARS, COMBINATIONS, METHOD OF SYNTHESIS OF (-)-6-CHLORO- -4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4- -DIHYDRO-2H-3,1-BENZOXAZINE-2-ONE |
1993 |
- Jang Stiven D.
- Britcher Sjuzn F.
- Pejn Linda S.
- Tran Likkhan O.
- Lamma Vill'Jam K. Ml.
|
RU2186775C2 |
GEMINALLY SUBSTITUTED CYANOETHYLPYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS |
2014 |
- Chajlders Mettyu Llojd
- Fuller Piter
- Gerin Devid
- Katts Dzhejson Devid
- Pu Tsinlin
- Skott Mark E.
- Tompson Kristofer F.
- Martines Mishel
- Folkon Deniell
- Torres Luis
- Deng Jongki
- Kurukulasuriya Ravi
- Tszen Khunbo
- Baj Yunfyn
- Kun Norman
- Lyu Yujmej
- Chzhen Chzhisyan
|
RU2664533C2 |