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2 360 910

(13)

(51)

IPC

C07D401/04(2006-01-01)

C07D403/04(2006-01-01)

C07D407/04(2006-01-01)

C07D409/04(2006-01-01)

C07D413/04(2006-01-01)

C07D417/04(2006-01-01)

A61K31/4196(2006-01-01)

A61K31/4245(2006-01-01)

A61P3/10(2006-01-01)

(21) (22)

Application

2005122936/04, 2003-12-16

(24)

Start date

2003-12-16

(22)

Actual filing date

2003-12-16

(45)

Published

2009-07-10

(72)

Inventor

Uoddell Sherman T.Santorelli Dzhina M.Maletik Milana M.Leeman Aaron G.Gu Sin'Grehkhem Donal'D U.Balkovets Dzhejms M.Aster S'Juzan D.

(73)

Holder

Merk Ehnd Ko., Ink.

TRIAZOLE DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROIDDEHYDROGENASE-1 Russian patent published in 2009 - IPC C07D401/04 C07D403/04 C07D407/04 C07D409/04 C07D413/04 C07D417/04 A61K31/4196 A61K31/4245 A61P3/10

Abstract RU 2360910 C2

FIELD: chemistry; medicine.

SUBSTANCE: in novel triazole derivatives of general formula I or their pharmaceutically acceptable salts R⁴ is hydrogen; X is selected from group, consisting of single bond, NH- and groups: , values of R¹-R³ radicals are given in description, pharmaceutical composition containing them, and application of novel compounds for obtaining medication for treating hyperglycemia, insulin-resistance, type 2 diabetes, fat exchange derangements, obesity, atheroslerosis and metabolic syndrome.

EFFECT: medications possess higher efficiency.

26 cl, 8 ex, 2 tbl

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RU 2 360 910 C2

Authors

Uoddell Sherman T.

Santorelli Dzhina M.

Maletik Milana M.

Leeman Aaron G.

Gu Sin'

Grehkhem Donal'D U.

Balkovets Dzhejms M.

Aster S'Juzan D.

Dates

2009-07-10—Published

2003-12-16—Filed