FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes new substituted heterocycles of the general formula (I) 
where values R′-R5, X are given in p. 1 of the invention claim. Compounds are antagonists of tachykinin receptors and show the efficiency for treatment of patients with inflammatory sicknesses, pains or migraine and asthma. Also, some of these substances are agents blocking calcium channel and they can be benefit for treatment of patients with cardiovascular disorders, for example, angina, hypertensia and ischemia. Invention describes a pharmaceutical composition based on compounds of the formula (I) and a method of blockade of neurokinin-1 receptors in mammals also. EFFECT: improved method of receptor blocking, valuable curative properties. 9 cl, 7 dwg, 67 ex
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