FIELD: pharmaceutical industry. SUBSTANCE: described are new nonpeptide antagonists of tachikinin receptors of general formula: 
wherein R,R1,R2,R3,R4,R8,n,m are as defined in claim 1. Described is pharmaceutical composition which is antagonist of NK-1 and NK-2 receptors and based on compounds of general formula I: EFFECT: improved properties of antagonists of tachikinin receptors. 13 cl, 4 dwg, 188 ex, 2 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| (R)-3-(1H-INDOLE-3-YL)-1-[N-(2-METHOXYBENZYL)ACETYLAMINO]-2- -[N-(2-(4-PIPERIDINE-1-YL)PIPERIDINE-1-YL)ACETYL)AMINO]PROPANE DIHYDROCHLORIDE TRIHYDRATE AND PHARMACEUTICAL COMPOSITION | 1995 |
|
RU2151769C1 |
| USE OF 6-HETEROCYCLO-4-AMINO-1,3,4,5-TETRAHYDROBENZ[CD]INDOLE USED IN VOMITING OR NAUSEA AT MOVING, PHARMACEUTICAL COMPOSITION | 1993 |
|
RU2138262C1 |
| CYCLIC PEPTIDE DERIVATIVES OF PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD, AND PHARMACEUTICAL COMPOSITION | 1993 |
|
RU2129562C1 |
| NOVEL 1H-INDOLE-3-ACETAMIDES AS INHIBITORS OF SPLA AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 1994 |
|
RU2162463C2 |
| DERIVATIVES OF 1-CARBA-(1-DETIA)-CEPHEME | 1993 |
|
RU2107067C1 |
| METHOD OF SYNTHESIS OF 5-SUBSTITUTED PYRROLO[2,3-α]- -PYRIMIDINES | 1993 |
|
RU2127274C1 |
| METHOD OF SYNTHESIS OF 3-EXOMETHYLENECEPHAME SULFOXIDE ESTER | 1992 |
|
RU2010795C1 |
| DERIVATIVES OF GLYCOPEPTIDE OR THEIR SALTS, METHOD OF SYNTHESIS, PHARMACEUTICAL COMPOSITION | 1995 |
|
RU2145609C1 |
| DERIVATIVES OF SULFONYLUREA OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, A METHOD OF THEIR SYNTHESIS AND A PHARMACEUTICAL COMPOSITION BASED ON DERIVATIVES OF SULFONYLUREA SHOWING ANTITUMOR ACTIVITY | 1994 |
|
RU2127259C1 |
| TRIPEPTIDE DERIVATIVES AS R- OR RS-FORMS OR THEIR PHARMACEUTICALLY ACCEPTABLE NONTOXIC SALTS, PHARMACEUTICAL COMPOSITION | 1991 |
|
RU2077538C1 |
