FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes the novel compound: (R)-3-(1H-indole-3-yl)-1- -[N-(2-methoxybenzyl)acetylamino] -2-[N-(2-(4-(piperidine-1-yl)- -piperidine-1-yl)acetyl)amino] propane dihydrochloride trihydrate that is useful as compound binding tachykinin receptors and as antagonists or agonists of different tachykinins. Invention describes also pharmaceutical composition containing the above indicated compound. EFFECT: valuable pharmacological properties of compound. 3 cl, 8 ex
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Year |
Author |
Number |
| NONPEPTIDE ANTAGONISTS OF TACHIKININ RECEPTORS |
1994 |
- Stefen Sung Jong Cho
- Tomas Alan Krouehll
- Brjus Donal'D Gitter
- Filip Artur Khipskind
- Dzhejms Dzheffri Khubert
- Dzhozef German Krushinskij
- Karen Linn Lobb
- Brajen Stefen Mjul'
- Dzhejms Artur Nikson
|
RU2140921C1 |
| CIS-(-)-4-[(1(2)H-TETRAZOLE-5-YL)-METHYL]-2-PIPERIDINE CARBOXYLIC ACID AND PHARMACEUTICAL COMPOSITION SHOWING ACTIVITY AS AN ANTAGONIST OF EXCITEMENT AMINO ACID RECEPTORS |
1991 |
|
RU2089546C1 |
| MACROCYCLIC BIS-INDOL MALEIMIDE DERIVATIVES, METHOD OF PREPARATION THEREOF (VARIANTS) AND PHARMACEUTICAL COMPOSITION |
1994 |
- Vill'Jam Frehnsis Khit
- Majkl Robert Dzhirosek
- Dzhon Khehmpton Makdonal'D Iii
- Kristofer Dzhon Rito
|
RU2147304C1 |
| METHOD OF SYNTHESIS OF (S)--1÷1-N,N-DIMETHYL-3-(1-NAPHTHALINYL- -HYDROXY)-3-(2-THIENYL)-PROPANEAMINE AND (S)-±-N,N-DIMETHYL- -3-(1-NAPHTHALINYLHYDROXY)-3-(2-THIENYL)-PROPANEAMINE PHOSPHATE |
1994 |
|
RU2127269C1 |
| NOVEL 1H-INDOLE-3-ACETAMIDES AS INHIBITORS OF SPLA AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
1994 |
- Nikolas Dzhejms Bakh
- Robert Dilejn Dillard
- Sjuzan Ehlizabet Drakhajm
- Robert Bell Khermann
- Richard Uolter Shevits
|
RU2162463C2 |
| USE OF 6-HETEROCYCLO-4-AMINO-1,3,4,5-TETRAHYDROBENZ[CD]INDOLE USED IN VOMITING OR NAUSEA AT MOVING, PHARMACEUTICAL COMPOSITION |
1993 |
- Richard Nolan Bukher
- Majkl Ehdvard Flof
- Dehvid Ehrnst Lokhorn
- Charl'Z Dzhon Paget
- Dzhon Menert Shos
|
RU2138262C1 |
| DERIVATIVES OF 1-CARBA-(1-DETIA)-CEPHEME |
1993 |
- Robert Dzhon Ternanski[Us]
|
RU2107067C1 |
| USE OF 2-PHENYL-3-AROYLBENZOTHIEPHENES, THEIR SALTS OR SOLVATES FOR INHIBITION OF OSSEOUS TISSUE LOSS, PHARMACEUTICAL COMPOSITION CONTAINING 2-PHENYL-3-AROYLBENZOTHIEPHENES AND THEIR SALTS OR SOLVATES |
1995 |
- Majkl Uil'Jam Drejper[Us]
|
RU2100024C1 |
| 4-AMINO-6-SUBSTITUTED TETRAHYDROBENZ-[C,D]-INDOLES |
1992 |
- Majkl Ehdvard Flaf[Us]
- Majkl Dzhon Martinelli[Us]
- Dzhon Menert Skauz[Us]
|
RU2073672C1 |
| PIPERIDINE COMPOUNDS AND PHARMACEUTICAL COMPOSITION SHOWING ACTIVITY AS ANTAGONIST OF OPIOID PERIPHERAL ACTION |
1992 |
- Baddi Judzhin Kantrell[Us]
- Dennis Majkl Tsimmerman[Us]
|
RU2076863C1 |
